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Open Orphan #ORPH – Additional Laboratory Services Contracts Signed with NOBACZ & Nearmedic International
Open Orphan plc (ORPH), a rapidly growing specialist CRO pharmaceutical services company which is the world leader in the testing of vaccines and antivirals using human challenge clinical trials is pleased to announce that as part of opening up its hVIVO laboratory services to third parties that it has signed 3 new contracts with third parties; NoBACZ Ltd who are a spin-out company of the University of Cambridge, a new second contract with Nearmedic International Ltd and a contract to run in-vitro testing from its laboratory for a Cambridge, Massachusetts biotech.
NoBACZ Ltd is developing an environmentally friendly antimicrobial, antiviral coating that prevents common-touch surfaces from being a major source of infection transmission during and beyond the COVID-19 outbreak. The innovative, customisable antimicrobial coating has a multitude of applications across public spaces and industries. Applied as a liquid, the NoBACZ product is adhesive and water repellent and sets into a solid but flexible barrier that is robust enough to form a semi-permanent coating on a wide variety of surfaces. The product’s composition can be fine-tuned to produce a thin or thick coating to suit different surfaces and materials, with the ability to adapt the product’s life-span before it naturally degrades such that there is no need to manually remove it.
NoBACZ Ltd is working with hVIVO, at its state-of-the-art laboratory in East London, to test its products against a range of viruses, including coronaviruses and ultimately, against SARS-CoV-2, the virus strain that causes COVID-19 disease. If successful, the long-lasting coating can be applied to high-touch surfaces in public transport, office buildings, hospitals, gyms, care-homes, and supermarkets.
hVIVO has also recently signed a contract to run in vitro testing from its laboratory for a Cambridge, Massachusetts based biotech company. In addition, hVIVO had also signed another contract with Nearmedic International Ltd, the Company’s second in recent times, to support the development of a RegG3 drug as a treatment for COVID-19 followed by the expansion of this product into several disease areas such as Cystic Fibrosis.
As announced at Open Orphan’s recent fundraise, the group is expanding its virology and laboratory testing services to third parties. This provision of third-party laboratory services is a growth area for the Group as numerous biotechnology companies and small cap pharmaceutical companies around the world do not have their own virology laboratory. hVIVO has a unique state-of-the-art virology laboratory which it needs to run its own clinical trials, however, quite often in the past it was no more than 15% to 20% utilised. Therefore, going forward it makes great business sense to build up the laboratory services to use this underutilised capacity, i.e. our existing staff resources and facilities, to build a more profitable and sustainable business going forward. These contracts are further evidence of the Open Orphan Group executing on its strategy of building out additional and sustainable revenue lines from each of its Group companies going forward and is in line with the strategy of becoming a leading pharma services provider to the viral, and respiratory diseases sector of the pharmaceutical industry.
Cathal Friel, Executive Chairman of Open Orphan, said:
“We are now continuing to sign additional new virology services contracts with third party customers and, as such, this is delivering upon one of our key commitments from when we acquired hVIVO earlier this year that, as part of our growth strategy, we were going to expand the range of our service offerings to third party pharmaceutical and biotech companies. I am excited by this area of growth for Open Orphan as we seek to maximise the value out of our fantastic facilities in East London.”
Jonathan Powell, CEO of NoBACZ said:
“We are delighted to be working with hVIVO, a world-leading virology laboratory and pioneer of viral challenge studies, in our efforts to evaluate NoBACZ’s ground-breaking coating technology and its effectiveness at contact-killing respiratory viruses. hVIVO has the requisite experience and professional commercial focus to execute our pivotal studies rapidly and efficiently, allowing us to move forward in our ambitions to provide a quick-to-market solution for protecting the public against a resurgence of COVID-19 or similar outbreaks.”
Rupert Holms, Chairman of Nearmedic said:
“hVIVO and Open Orphan have the unique combination of skills which shall help Nearmedic to get its novel ezrin peptide technology to the global pharmaceutical markets and help in the fight against the COVID-19 pandemic”
For further information please contact
Open Orphan plc |
+353 (0)1 644 0007 |
Cathal Friel, Executive Chairman |
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Arden Partners plc (Nominated Adviser and Joint Broker) |
+44 (0)20 7614 5900 |
John Llewellyn-Lloyd / Benjamin Cryer / Dan Gee-Summons |
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finnCap plc (Joint Broker) |
+44 (0) 20 7220 500 |
Geoff Nash / James Thompson/ Richard Chambers |
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Davy (Euronext Growth Adviser and Joint Broker) |
+353 (0)1 679 6363 |
Anthony Farrell |
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Camarco (Financial PR) |
+44 (0)20 3757 4980 |
Tom Huddart / Hugo Liddy |
Irish Independent – Open Orphan subsidiary starts testing drug for treating Covid-19
A subsidiary of Open Orphan has started testing a drug that could potentially treat Covid-19.
Open Orphan is a Europe- focused pharma services company specialising in rare disease and so-called orphan drugs.
The tests are being carried out by its London-based subsidiary Hvivo on behalf of its client Nearmedic International.
The drug being tested has both potential anti-viral and anti-inflammatory activity, and therefore could reduce both virus infectivity and disease severity respectively, a statement from Open Orphan said.
Hvivo will be testing its utility against a panel of viruses that include influenza virus, “normal”, circulating betacoronavirus and ultimately SARS-CoV2 (Covid-19).
Cathal Friel, chairman of Open Orphan, said: “We are very happy to be assisting in the battle against Covid-19 and are delighted to be working with Nearmedic International.”
“Hvivo is a world leading provider of services to global vaccine and antiviral development companies and our scientists have considerable knowledge from previous anti-viral trials which gives us confidence in our testing,” he added
Link here for original article
Irish Times – Open Orphan to test Covid-19 drug through London subsidiary
Pharma company steps up fight against virus that has infected more than 2.6m worldwide
by Ciara O’Brien
Dublin-listed pharma services company Open Orphan has begun testing an anti-viral treatment for Covid-19 through its London-based subsidiary Hvivo.
The testing is being carried out on behalf of Nearmedic International, a specialist pharmaceutical, biotechnological and medical company headquartered in Moscow.
The drug being tested is potentially anti-viral and anti-inflammatory, and could reduce both virus infectivity and disease severity. It will be tested against a panel of viruses including the influenza virus, circulating betacoronavirus and Covid-19.
“Hvivo is a world leading provider of services to global vaccine and antiviral development companiesand our scientists have considerable knowledge from previous anti-viral trials which gives us confidence in our testing,” said Cathal Friel, executive chairman of Open Orphan.
Open Orphan agreed to merge with UK-based Hvivo last year in a £30 million tie-up that classified as a reverse takeover. Hvivo is a clinical trial business that can accelerate drug and vaccine development.
The company previously said it would restart a project whereby humans will be deliberately infected with a coronavirus as part of efforts to develop a vaccine to Covid-19.The project was originally suspended by Hvivo after concerns there was insufficient market demand for the product.
Open Orphan #ORPH – Testing of anti-viral for treating COVID-19 underway
Open Orphan plc (ORPH) the rapidly growing specialist CRO pharmaceutical services company which has a focus on orphan drugs and is a world leader in the provision of virology and vaccine challenge study services, is pleased to announce that its London-based subsidiary hVIVO has commenced the testing of an anti-viral for treating COVID-19 on behalf of its client Nearmedic International Ltd.
hVIVO has initiated work on this contract with Nearmedic International Ltd, a specialist pharmaceutical, biotechnological and medical business headquartered in Moscow, to test using hVIVO’s virology expertise and laboratory capability an anti-viral drug with potential utility for treating SARS-CoV2 (COVID-19) infections. This drug has both potential anti-viral and anti-inflammatory activity and as such could reduce both virus infectivity and disease severity respectively.
hVIVO will be testing its utility against a panel of viruses to include influenza virus, “normal”, circulating betacoronavirus and ultimately SARS-CoV2 (COVID-19).
Cathal Friel, Executive Chairman of Open Orphan, commented:
“We are very happy to be assisting in the battle against Covid-19 and are delighted to be working with Nearmedic International Ltd. hVIVO is a world leading provider of services to global vaccine and antiviral development companiesand our scientists have considerable knowledge from previous anti-viral trials which gives us confidence in our testing. We look forward to updating the market on a regular basis in the weeks and months ahead.”
For further information please contact:
Open Orphan plc |
|
Cathal Friel, Executive Chairman |
+353 (0)1 644 0007 |
Trevor Phillips, Chief Executive Officer |
+44 (0)20 7347 5350 |
Arden Partners plc (Nominated Adviser and Joint Broker) |
+44 (0)20 7614 5900 |
John Llewellyn-Lloyd / Benjamin Cryer
|
|
Davy (Euronext Growth Adviser and Joint Broker) |
+353 (0)1 679 6363 |
Anthony Farrell
|
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Camarco (Financial PR) |
+44 (0)20 3757 4980 |
Tom Huddart / Daniel Sherwen |
Notes to Editors:
Open Orphan is a rapidly growing specialist CRO pharmaceutical services company which has a focus on orphan drugs and is a world leader in the provision of virology and vaccine challenge study services and viral laboratory services. It has Europe’s only 24-bedroom quarantine clinic with onsite virology lab in Queen Mary’s Hospital London. hVIVO supports product development for customers developing antivirals, vaccines and respiratory therapeutics, all particularly relevant and topical in the environment of heightened awareness of Covid-19 in 2020. The Company also has a leading portfolio of 8 viral challenge study models which are: 2 FLU, 2 RSV, 1 HRV, 1 Asthma, 1 cough and 1 COPD viral challenge models. As announced in early March, Open Orphan is rapidly advancing a Coronavirus challenge study model and expects to be very active with many companies in the development of a Covid-19 vaccine. No other company in the world has such a portfolio, with only two competitors globally having 1 challenge study model each.
Open Orphan comprises of two commercial specialist CRO services businesses (Venn and hVIVO) and is developing an early stage orphan drug genomics data platform business. This platform captures valuable genetic data from patient populations with specific diseases with designated orphan drug status and incorporating AI tools. In June 2019, Open Orphan acquired AIM-listed Venn Life Sciences Holdings plc in a reverse take-over and in January 2020 it completed the merger with hVIVO plc. Venn, as an integrated drug development consultancy, offers CMC (c hemistry, manufacturing and controls) , preclinical, Phase I & II clinical trials design and execution. The merger with hVIVO created a European full pharma services company broadening the Company’s customer base and with complementary specialist CRO services, widened the range of the Company’s service offerings.