Home » Posts tagged 'european congress of radiology'
Tag Archives: european congress of radiology
TexRAD presentation at European Congress of Radiology (ECR) – Feedback (FDBK)
Today’s presentation by Dr. Alessandro Scavuzzo from Brescia University Hospital at the European Congress of Radiology further demonstrates the utility of TexRAD on MRI in a new application in cardiovascular disorders (e.g. dilated cardiomyopathy) specifically highlighting the ability of TexRAD MR texture analysis as a non-invasive imaging biomarker showing association with the clinical score and patient outcome
Provided by University of Brescia.
Presentation Details
Presentation Title: Role of late gadolinium enhancement, myocardium native T1 value and texture analysis in patients affected by dilated cardiomyopathy: clinical score and outcome correlation.
Purpose: To correlate late gadolinium enhancement (LGE) myocardium T1 value, texture analysis and the outcome in patients affected by dilated cardiomyopathy (DMC).
Methods and Materials: Retrospective evaluation on 104 DMC affected patients who underwent cardiac MR (CMR) between January 2012 and May 2015. Exam protocol included morphologic sequences, cine MR, native T1 mapping and after gadolinium PSIR sequences. LGE was analysed drawing ROIs on short-axis PSIR, T1 delineating the cardiac septum on native short-axis ShMOLLI and texture analysis delineating the septum on short-axis cine MR using TexRAD software. Outcome was set as major cardiac events (MACE) 6 months within the exam
Results: 53/104 patients presented LGE and they showed a higher percentage of MACE compared to patients without LGE (37% vs. 7% respectively, p=0.001). The extension of LGE did not correlate with MACE, the ejection fraction or the end diastolic volumes (t test, p=ns). T1 was measured on 34 patients, 21 with LGE (mean 1033msec) and 13 without LGE.
(mean 1008msec)(p=ns). Significant difference was shown between T1 of patients with MACE (11/34, mean 1045msec) and without MACE (23/24, mean 1011msec)(p=0.02). Texture analysis showed correlation between patients with and without MACE, with kurtosis at 1mm filter being the most significant value (t test, p=0.0019).
Conclusion: Both the presence of LGE and native T1 value of myocardium correlate with MACE. Correlation between T1 and LGE has not been proved. Texture analysis has demonstrated a potential on defining diffuse myocardium fibrosis (particularly with thin filters) and is easily applicable, but is still not supported by enough literature data.
4 – Forthcoming TexRAD presentations at European Congress of Radiology (ECR) – Feedback (FDBK)
Presentation at forthcoming European Congress of Radiology (March 1-5 2017)
Provided by University of Brescia.
Presentation Details
Presentation Title: Correlation between locally advanced HPV positive oropharyngeal squamous cell carcinoma and quantitative MRI parameters
Author Block: M. Leali, E. Tononcelli, E. Lleshaj, A. Grammatica, M. Ravanelli, D. Farina, R. Maroldi; Brescia/IT
(The presenting author is underlined.)
Disclosure Block: M. Leali: None. E. Tononcelli: None. E. Lleshaj: None. A. Grammatica: None. M. Ravanelli: None. D. Farina: None. R. Maroldi: None.
Session Number: SS 308
Topic: Head and Neck
Session Title: Head and neck cancer: value of multiparametric and advanced imaging techniques
Session Date/Time: Wednesday Mar 1 2017, 14:00 – 15:30
Room: 09/L 8
Below is a view of your accepted abstract:
Purpose: to evaluate the association between quantitative MR parameters and HPV status in advanced oropharyngeal squamous cell carcinoma (OPSCC).
Methods and Materials: 24 patients with locally advanced OPSCC underwent pre-treatment MR. Histogram analysis was performed on TSE-T2, DWI and post-gadolinuim 3D-VIBE sequences before and after application of a Laplacian of Gaussian spatial scale filter (ssf) at the primary tumor site. Search of HPV DNA on biopsies was performed to evaluate HPV status. Mann-Whitney test was used to assess differences in quantitative MR parameters between HPV+ and HPV- groups.
Results: 10 patients were HPV-positive (41,7%). Mean ADC was significantly lower in HPV+ compared to HPV- patients (0.83 vs 1.04 x 10-3mm2/s respectively, p=0.015). Skewness measured on 3D-VIBE with 1mm-ssf was significantly higher in HPV+ compared to HPV- patients (p=0.03).
Conclusion: quantitative MR parameters, especially mean ADC, may reflect microstructural differences between HPV+ and HPV- OPSCC.
Link to ECR presentation page here
3 – Forthcoming TexRAD presentations at European Congress of Radiology (ECR) – Feedback (FDBK)
Presentation at forthcoming European Congress of Radiology (March 1-5 2017)
Provided by University of Brescia.
Presentation Details
Presentation Title: CT texture analysis as a predictor of response to therapy and prognosis in patients with metastatic renal cell carcinoma treated with first-line tyrosine kinase inhibitors
Author Block: G. Bonera, G. Agazzi, M. Ravanelli, D. Farina, V. Ferrari, A. Berruti, R. Maroldi; Brescia/IT
(The presenting author is underlined.)
Disclosure Block: G. Bonera: None. G. Agazzi: None. M. Ravanelli: None. D. Farina: None. V. Ferrari: None. A. Berruti: None. R. Maroldi: None.
Session Number: SS 216
Topic: Oncologic Imaging
Session Title: Imaging and predicting treatment response and outcome in oncology
Session Date/Time: Wednesday Mar 1 2017, 10:30 – 12:00
Room: 19/M 3
Below is a view of your accepted abstract:
Purpose: To investigate if texture analysis (TA) on pretreatment contrast-enhanced CT (CECT) images can predict response to tyrosine kinase inhibitors (TKI) and prognosis in patients with metastatic renal cell carcinoma (mRCC).
Methods and Materials: 65 pretreatment CECT studies of mRCC patients treated with first-line TKI were retrospectively reviewed. Objective response was assessed every 3 months according to RECIST 1.1 and modified Choi (mChoi) criteria. TA was performed on a 5-mm-thick central slice for each target lesion using a commercially available software (TexRAD Ltd, UK). Primary texture features and a novel HeteroDensity Index (HDI), accounting for size-standardised heterogeneity and mean pixel density, were quantified using different spatial-scale filters (ssf). Per-patient texture features were correlated with objective response, progression-free and overall survival (PFS, OS) using logistic regression and survival analysis, statistical significance was corrected to control false discovery rate.
Results: Primary texture features were not able to discriminate responders and non-responders. HDI obtained with a 3-mm ssf (ssf3) was positively correlated with objective response (odds ratio 0.14 for RECIST and 0.2 for mChoi criteria, p 0.018 and 0.026, respectively). Low ssf3 HDI was associated with worse PFS (hazard ratio 4.14, p 0.0001) and OS (hazard ratio 3.36, p 0.0008).
Conclusion: TA on pretreatment CECT helps to predict objective response and prognosis in mRCC patients treated with first-line TKI..
Link to ECR presentation page here
2 – Forthcoming TexRAD presentations at European Congress of Radiology (ECR) – Feedback (FDBK)
Presentation at forthcoming European Congress of Radiology (March 1-5 2017)
Provided by University of Brescia.
Presentation Details
Presentation Title: CT texture analysis in metastatic lung adenocarcinoma treated with tyrosine kinase inhibitors: prediction of survival
Author Block: J. Cardinale, V. Bettoni, G. Agazzi, M. Ravanelli, E. Roca, D. Farina, A. Berruti, R. Maroldi; Brescia/IT
(The presenting author is underlined.)
Disclosure Block: J. Cardinale: None. V. Bettoni: None. G. Agazzi: None. M. Ravanelli: None. E. Roca: None. D. Farina: None. A. Berruti: None. R. Maroldi: None.
Session Number: SS 204
Topic: Chest
Session Title: Lung cancer: from diagnosis to prognosis
Session Date/Time: Wednesday Mar 1 2017, 10:30 – 12:00
Room: 06/O
Below is a view of your accepted abstract:
Purpose: To assess the predictive and prognostic value of pre-treatment CT texture features in lung adenocarcinoma treated with tyrosine kinase inhibitors (TKI).
Methods and Materials: Texture analysis was performed with a commercially available software (TexRAD Ltd, UK) on pre-treatment contrast-enhanced CT studies of 27 patients with metastatic lung adenocarcinoma treated by TKI. Texture features were quantified on a 5-mm thick central slice of the primary tumour and were correlated with progression-free and overall survival (PFS and OS) using uni- and multi-variable analysis.
Results: Mean PFS and OS were 77.4±71 and 110±87 weeks, respectively. At multivariable analysis, kurtosis of 3-mm texture was independently correlated with PFS, tumours with high kurtosis (>0.98) had a 11.4 relative risk of progression compared with tumours with low kurtosis (p<0.0001); kurtosis on unfiltered images was correlated with OS, tumours with high kurtosis (>1.74) had a 10.3 relative risk of death compared with tumours with low kurtosis (p 0.0006). Among clinical variables, only age<60 years correlated with shorter PFS (relative risk 4.1, p0.02).
Conclusion: Texture features, in particular kurtosis, are strongly associated with PFS and OS in lung adenocarcinoma treated with TKI.
Link to ECR presentation page here
1- Forthcoming TexRAD presentations at European Congress of Radiology (ECR) – Feedback (FDBK)
Presentation at forthcoming European Congress of Radiology (March 1-5 2017)
Provided by Oslo University Hospital.
Presentation Title: Texture analysis on diffusion-tensor imaging: discriminating glioblastomas from single brain metastasis
Author Block: K. Skogen1, A. Schulz1, E. Helseth1, J.B. Dormagen1, B. Ganeshan2, A. Server1; 1Oslo/NO, 2London/GB
(The presenting author is underlined.)
Disclosure Block: K. Skogen: Shareholder; Yes. Speaker; Yes. A. Schulz: None. E. Helseth: None. J.B. Dormagen: None. B. Ganeshan: Shareholder; Yes. A. Server: None.
Session Number: SS 711
Topic: Neuro
Session Title: Brain tumours: lesion characterisation and treatment evaluation
Session Date/Time: Thursday Mar 2 2017, 14:00 – 15:30
Room: 11/E2
Below is a view of your accepted abstract:
Purpose: Texture analysis has been used to stage, differentiate and predict prognosis in many oncologic tumours. It has been used on CT, MRI and PET. The purpose of this study was to determine the diagnostic accuracy of discriminating glioblastoma (GBM) from single brain metastasis (MET) by assessing the heterogeneity of both the solid tumour and the peritumoural oedema with MRI texture analysis (MRTA).
Methods and Materials: Preoperative MRI examinations done on a 3T scanner of 44 patients were included, 23 GBM and 21 MET. MRTA was performed on the DTI in a representative ROI. The MRTA was assessed using a commercially available research software program (TexRAD)
which applies a filtration histogram technique for characterising tumour and peritumoural heterogeneity. The filtration step selectively filters and extracts texture features at different anatomical scales varying from 2mm (fine) to 6mm (coarse). Heterogeneity quantification was obtained by the statistical parameter entropy. A threshold value to differentiate GBM from MET with sensitivity and specificity was calculated by receiver operating characteristics (ROC) analysis.
Results: Quantifying the heterogeneity of the solid part of the tumour showed no significant difference between GBM and MET. However the heterogeneity of the GBMs peritumoural oedema was significantly higher than the oedema surrounding MET, differentiating them with a sensitivity of 90% and specificity of 80%.
Conclusion: Assessing the peritumoural heterogeneity can increase the radiological diagnostic accuracy when discriminating GBM and MET. This will facilitate the medical staging and optimise the planning for surgical resection of the tumour and postoperative management.
Link to ECR presentation page here