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Advanced Oncotherapy (AVO) – Holdings in Company

By administrator in Advanced Oncotherapy (AVO) on 12th May 2016.

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESⁱ


1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ⁱⁱ				Advanced Oncotherapy plc
2 Reason for the notification (please tick the appropriate box or boxes):
An acquisition or disposal of voting rights
An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached
An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments
An event changing the breakdown of voting rights :
Other (please specify):	CHANGE IN NATURE : RETURN OF LOANED SHARES				√
3. Full name of person(s) subject to the notification obligation: ⁱⁱⁱ		Aviva plc & its subsidiaries
4. Full name of shareholder(s) (if different from 3.):^iv		Registered Holder: Available on Request 176,711* BNY Norwich Union Nominees Limited 4,008,535* Chase (GA Group) Nominees Limited 45,367,297* State Street Nominees Limited 8,214,364* *denotes direct interest Chase (GA Group) Nominees Limited 14,325,673 Chase Nominees Limited 3,054,271 Vidacos Nominees Limited 7,848,474
5. Date of the transaction and date on which the threshold is crossed or reached: ^v		11 May 2016
6. Date on which issuer notified:		12 May 2016
7. Threshold(s) that is/are crossed or reached: ^{vi, vii}		3% to 4% Change at Direct Interest Level (Box 8A)

8. Notified details:
A: Voting rights attached to shares ^{viii, ix}
Class/type of shares if possible using the ISIN CODE	Situation previous to the triggering transaction				Resulting situation after the triggering transaction
	Number of Shares		Number of Voting Rights		Number of shares	Number of voting rights			% of voting rights ^x
					Direct	Direct ^xi		Indirect ^xii	Direct		Indirect
Ordinary Shares GB00B16JQ761	83,856,293*		83,856,293*		82,995,325	57,766,907		25,228,418	4.07%		1.78%

* Includes right to recall loaned shares (1,163,720)
B: Qualifying Financial Instruments
Resulting situation after the triggering transaction
Type of financial instrument		Expiration date ^xiii		Exercise/ Conversion Period ^xiv			Number of voting rights that may be acquired if the instrument is exercised/ converted.			% of voting rights
RIGHT TO RECALL LOANED SHARES		N/A		N/A			3,720 * * Direct Interest			0.0003%

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments ^{xv, xvi}
Resulting situation after the triggering transaction
Type of financial instrument	Exercise price	Expiration date ^xvii	Exercise/ Conversion period ^xviii	Number of voting rights instrument refers to	% of voting rights ^{xix, xx}
					Nominal	Delta

Total (A+B+C)
Number of voting rights	Percentage of voting rights
82,999,045	5.85%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: ^xxi
The voting rights are managed and controlled by Aviva Investors Global Services Limited and Friends Provident International Limited, with the following chain of controlled undertakings:- Aviva Investors Global Services Limited: · Aviva plc (Parent Company) · Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc) · Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva Group Holdings Limited) · Aviva Investors Global Services Limited (wholly owned subsidiary of Aviva Investors Holdings Limited) Friends Provident International Limited: · Aviva plc (Parent Company) · Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc) · Aviva Life Holdings UK Limited (wholly owned subsidiary of Aviva Group Holdings Limited) · Friends Life FPG Limited (wholly owned subsidiary of Aviva Life Holdings UK Limited) · Friends Life FPL Limited (wholly owned subsidiary of Friends Life FPG Limited) · Friends Life Limited (wholly owned subsidiary of Friends Life FPL Limited) · Friends Life and Pensions Limited (wholly owned subsidiary of Friends Life Limited) · Friends Provident International Limited (wholly owned subsidiary of Friends Life and Pensions Limited)

Proxy Voting:
10. Name of the proxy holder:	See Section 4
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:	Figures are based on a total number of voting rights of 1,418,342,375 as per the Company’s Exercise of Warrants & Options & Issue of Shares announcement of 18 April 2016.
14. Contact name:	Neil Whittaker, Aviva plc
15. Contact telephone number:	01603 684420

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